This Phase I/IIa open-label study investigated the safety and efficacy of a multi-modal approach for vocal fold scarring and dysphonia. The intervention combined surgery, local administration of mesenchymal stromal cells, and voice training. The research focused on evaluating patient-reported outcomes and objective voice function, aiming to understand the impact of this novel therapeutic strategy. The findings from this study are significant as they explore a potentially innovative treatment for individuals experiencing voice impairment due to vocal fold scarring. By assessing both subjective patient experiences and measurable voice function, the research provides preliminary insights into the safety and preliminary effectiveness of mesenchymal stromal cell therapy coupled with voice training in this patient population. This work holds promise for future therapeutic development in the field of voice rehabilitation.
Original publication date: 2026 Apr 19
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